Mental health has historically been a stepchild of any health care system, with stigma and neglect the signal response to its challenges. Thankfully, that is changing, bringing new hope to the hundreds of millions of people who suffer from depression, anxiety disorders, and other debilitating conditions. As scientific knowledge about the brain deepens, and global activism raises awareness, therapeutic options are being transformed by new drugs, public education, and community-based solutions. In the US, insurers must now cover mental health services at the same level as other forms of medical care. Will new attitudes, a renewed focus on prevention, and better treatments bring the gift of mental wellbeing to more people?