Inequitable and untimely responses to COVID-19 and other pandemics. Disproportionate health impacts of climate change in Africa. Unequal financing mechanisms. Lack of reliable data and information. A dearth of leadership guided by human-centered values. These are a few of the many challenges that stand in the way of global health and development systems that work for all. Many are calling for a radical reimagination of systems that emphasizes power-shifting toward locally led leadership. Join Lola Adedokun, executive director of the Aspen Global Innovators Group, for an action-oriented conversation on how AGI is paving the path forward.